先天

embryonic period (contrasted with 後天|后天 [hou4 tian1]) / inborn / innate / natural

early / prior / former / in advance / first

day / sky / heaven

congenital; intrinsic; innate

congenital / intrinsic / innateness

congenital deficiency / inherent weakness

Down syndrome / trisomy 21

nature versus nurture

Down syndrome; trisomy 21

The first concern is affairs of state, enjoying the pleasure comes later. Quotation from essay On Yueyang Tower 岳陽樓記|岳阳楼记 by Song writer Fan Zhongyan 范仲淹[Fan4 Zhong4 yan1]

to be born with a weak constitution and suffer from ill health during one's life / (fig.) to be problematic from the start, and get even worse over time

birth defect